From traditional bioreactors to SUBs (Single-Use Bioreactors) Traditionally, bioreactors have been constructed from glass or stainless steel, and were designed to be reusable. However, in between batches, these vessels had to be carefully cleaned and sterilized prior to the next process being introduced. This cleaning process is labor-intensive and time-consuming. To reduce the costs and […]
Introduction to Non-Contact Flow Detection A non-contact flow meter utilizes ultrasonic technology to measure flow rate at critical points of various biotech processes. Ultrasonic technology enables non-contact detection of flow, independent of liquid composition (turbidity, charge, temperature etc.). ProA Flow ultrasonic flow sensors clamp on to the outside of flexible or rigid tubing, send ultrasonic […]
Soroosh Soltani1, Harleigh McNally1, Dmitriy Fedorenko1, Jasmine Tan1, Marcelo Luftman2, Justin Lussier2, Andrew Zydney3, Oleg Shinkazh1, * 1 Chromatan Corporation, 3 Spring House Innovation Park Suite 103, Lower Gwynedd, PA, 190022 PRO Analytics, LLC, Fairfield, NJ3 Department of Chemical Engineering, The Pennsylvania State University, University Park, PA 16802 * Communication concerning this manuscript should be […]
Dissolved CO2 in Bioprocess CO2 has many important roles in growth and maintenance of cell and bacteria cultures. CO2 acts as an additive product which affects a wide range of metabolic and critical process parameters. It is important to track dCO2 in your cultures for: Intracellular/Extracellular pH changes Glycosylation and Molecule Stability Lactate production Monitor […]
Introduction | What Is Spectroscopy? | Spectroscopic Techniques: Introduction to Spectroscopic Methods of Analysis in Bioprocessing: Luminescence | Absorption / NIR | Raman | Application of Raman Spectroscopy in Bioprocessing: PAT in Upstream | Raman in Upstream | PAT in Downstream | Raman in Downstream | Raman Analyzers Introduction The release of the FDA’s guidance […]
