Recombinant Therapeutic Proteins development and production operations require reliable and accurate biochemistry analyzers to characterize the cell culture process and maximize results through photometric analysis. Traditional membrane based (electrochemical) analyzers still in use in many labs present multiple problems including measurement drift and the need of high frequency maintenance. An advanced, more accurate technology based […]
pH and Dissolved Oxygen are critical parameters in bio fermentation and cell culture applications. The proper selection of probes in construction, quality and design is essential. However, to maximize the accuracy of results, it is equally important to utilize the right DO and pH probe calibration and maintenance techniques. pH Probe Calibration Techniques: Prior to […]
Optimization of Glutamine Measurement in Cell Culture Operations Current “membrane based” instrumentation utilized at a large cell culture manufacturing site has presented recurrent problems including non-repeatable, inaccurate metabolite analysis, especially of Glutamine. These membrane / electrochemical technologies have shown inherent flaws in measurement stability and excessive maintenance at multiple sites. Newer optical-based metabolite analyzers were evaluated to […]