End-to-end bioprocess digitization and contextualization
Advanced automated sampling with bioanalyzer integration
Advanced process control (APC) strategies
Modular, customizable control platforms for specific process tasks
At ProAnalytics, we leverage deep expertise in Process Analytical Technology (PAT) and hands-on experience across upstream and downstream operations in both PD and GMP environments to deliver intelligent, end-to-end bioprocess automation solutions. Whether you’re optimizing a single unit operation or digitizing your entire workflow, we tailor our solutions to meet your specific technical needs.
Bioprocess Software
AI-enabled Bioprocess Software
High-Throughput Bioprocessing
Modular, Customized Control Platforms
Bioprocess Software
Lucullus®
Lucullus® is a powerful, modular software platform that brings full automation and digitalization to bioprocessing. As a core component of bioprocess automation, it combines SCADA functionality with advanced tools for process planning, sample and material management, and system integration. Designed to meet Industry 4.0 standards, Lucullus ensures data integrity, streamlined workflows, and complete process transparency across all stages of bioproduction.
Comprehensive Software Solution for Bioprocess Digitalization
Parallel process monitoring
Comparison of real-time and historical data
Basic Process control
Start and stop processes on selected bioreactors and adapt process setpoints and parameters during the process
Advanced process control
Automation and real-time calculation
Data evaluation
3rd party analysis software integration (MATLAB, Python, DataHowLab …)
Process planning
Including equipment, procedures, parameters, sampling events and materials
Media and warehouse management
Electronic recipes and guided media preparation
Multi-user access
User, group and role management
Meets regulatory compliance
Regarding 21 CRF Part 11
Oversee data
Supervise your processes with easy access to all relevant information on-site and remotely
Basic
Data Acquisition, Process Monitoring
In modern bioprocessing, collecting data from diverse sources is essential to gain a comprehensive understanding and valuable insights into the process. With Lucullus®, this is realized through seamless connectivity and vendor-agnostic integration of various equipment.
The data is centrally stored in a structured and harmonized manner serving as a hub for consolidating the aggregated data. These foundations enable the subsequent application of process knowledge in advanced control strategies for automation.
Benefits
- Gain an Overview
Be on top of your running processes with centralized real-time monitoring. - Oversee the Data
Supervise your processes with easy access to all relevant information on-site and remotely. - Compare Processes
Evaluate performance by comparing running and historical processes at different scales. - Get Notified
Receive SMS and/or e-mail notifications of alarms and process events.
Information Management
In biomanufacturing, multiple stakeholders play critical roles — including lab technicians, engineers, data scientists and managers. Each user has distinct responsibilities and requires access to specific tools and information.
Lucullus® was purposefully developed to support to the unique needs of each user, offering manageable access and a harmonized interface. It ensures that all users have the necessary tools and information at their disposal, facilitating seamless collaboration and optimizing workflow efficiency.
Features
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User Management
Define users, groups and permissions via Lucullus® or existing LDAP -
Remote Access
Secure data access from everywhere in the network -
Audit Trail
Recording of all the user interactions during the process and projects -
Information Transfer
Seamless and harmonized data exchange between laboratories, departments and sites
Evaluation & Reporting
Lucullus® collects data from various sources across the entire bioprocess environment, storing it securely in one central location.
All process information is accessible for automated visualization, evaluation and batch reporting. Lucullus® provides efficient database search options, analysis tools, data export features and automated paperless documentation to support your needs.
Features
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Efficient filtering options to easily access all the historical process data
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Customized visualization of data in graphs or tables
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Advanced real-time process evaluation with integrated tools (e.g., smoothing, regression, integration)
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Programmable sequential evaluation for standardized process analysis and reporting
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Data export options for selected data sets and graphs in various formats
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Automatically generated reports using customized templates
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Data integration with 3rd party software such as databases and mathematical, statistical, and machine-learning tools
Control
Process Control & Automation
Lucullus® collects data from various sources across the entire bioprocess environment, storing it securely in one central location.
All process information is accessible for automated visualization, evaluation and batch reporting. Lucullus® provides efficient database search options, analysis tools, data export features and automated paperless documentation to support your needs.
Features
-
Efficient filtering options to easily access all the historical process data
-
Customized visualization of data in graphs or tables
-
Advanced real-time process evaluation with integrated tools (e.g., smoothing, regression, integration)
-
Programmable sequential evaluation for standardized process analysis and reporting
-
Data export options for selected data sets and graphs in various formats
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Automatically generated reports with customized templates
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Data integration with 3rd party software such as databases and mathematical, statistical, and machine-learning tools
Basic Control
The basic process control functionalities of Lucullus® include effortless process loading, initiation and termination, alongside the ability to modify setpoints and parameters. It also provides a comprehensive, real-time visualization of process states, alarms and events, thus ensuring a complete operational picture.
Centralized, uniform interface for overarching process control:
- Start and stop processes on selected bioreactors
- Adjust process setpoints and parameters during the process
- Apply predefined control strategies to single processes or process groups
- Configure customized notifications for alarms, process conditions or events
Advanced Control
The basic process control functionalities of Lucullus® include effortless process loading, initiation and termination, alongside the ability to modify setpoints and parameters. Additionally, it provides a comprehensive visualization of process states, alarms and events, offering a holistic overview.
Centralized, uniform interface for overarching process control:
- Start and stop processes on selected bioreactors
- Adapt process setpoints and parameters during the process
- Apply predefined control strategies to single processes or process groups
- Configure customized notifications for alarms, process conditions or events
Extended
Process Planning
The Lucullus® Planning tool empowers users to design future bioprocesses using a guided workflow. Operators can pre-define and schedule reactors and associated equipment, specify attributes and select control stepchains and alarms. This structured planning approach for future processes or process groups ensures smooth process starts and seamless knowledge transfer, facilitating efficient operations and effective process implementation.
1. Define process groups
2. Select devices and define attributes
3. Assign operations and media
4. Schedule processes and sampling events
Sample Management
Lucullus® significantly improves sample management and the efficiency of data assignment to relevant processes. While reactor sampling and sample processing are still performed manually, the samples are now stored in tubes labeled with barcodes. Lucullus® automatically creates unique barcodes for each sample, which are subsequently scanned at the off-line analyzer.
By generating a unique barcode ID, Lucullus® automatically imports the sample results upon completion of the analysis and assigns them to the corresponding process and process time, thereby streamlining data integration and ensuring accurate tracking of sample information.
Benefits:
- Manages samples efficiently by applying sampling strategies, defining methods and preparing tubes with barcode label
- Issues reminders during process execution to take a sample at predefined sampling intervals
- Records the exact timing of sampling in order to align on-line and off-line data
- Retrieves data automatically from at-line analyzers
- Can automate sampling and sample processing even further with the Numera® PAT system
- Uses sample data for advanced process control
Automated Sampling With Numera® System
The combination of the automated sampling system, Numera®, and the Process Information Management System, Lucullus®, enables the orchestration of the whole workflow covering sampling, measurement, process monitoring and control. Read more here
Material Management & Media Preparation
Lucullus® offers digital assistance for media lot preparation and seamless integration of raw material information. Lucullus® facilitates a streamlined workflow from media planning to media optimization through guided media preparation using electronic protocols. Lucullus® also enables efficient warehousing and ensures traceability of components throughout the process, enhancing overall efficiency and quality control.
Benefits:
- Check and monitor the availability and usage of compounds from the storage
- Reduce human errors during material handling due to guided workflows and barcode technology
- Manage your media recipes in a structured library
- Automatically record data in your media kitchen with integrated devices (e.g., pH meter, scales, etc.)
- Link media lots and compounds to experiments
- Use the information gained during experiments for media optimization, comparison, calculation and reporting
- Identify and monitor critical material attributes
Optional: 21 CFR Part 11 Compliancy
Lucullus® is designed to fulfill the requirements for electronic records and electronic signatures for GMP applications. It is compliant with the FDA 21 CFR Part 11 guideline.
Access Security
The Access Security includes features such as the use of a unique combination of user ID and password, customizable password security settings, comprehensive logging of access security actions in an audit trail, and extensive user management capabilities for roles and groups.
Electronic Signature
Lucullus® enforces the authorization of defined interactions by authorized users. Confirmation of changes is requested via pop-up windows. The following information is stored in the audit trail: reason, timestamp and printed username.
Audit Trail
Lucullus® provides a continuous audit trail that is protected against deactivation and tampering. It tracks the user interactions and all events during a process. A second audit trail at the database level logs all changes made in system configuration.
Archiving and Retrieval
The Lucullus® interface is designed to prevent process deletion and raw data modification to ensure data integrity. A robust data-integrity checking mechanism prevents the deletion of resources associated with active processes and serves as an additional layer of protection to ensure data consistency and reliability.
AI-Enabled Bioprocess Software
DataHow
Bioprocess Modeling Solutions
DataHowLab, from DataHow, is a unique digital bioprocess development solution created to support process development teams’ work more effectively and efficiently using a model-based methodology. Their bioprocess modeling solutions are built around innovative technologies such as hybrid models, transfer learning, and digital twins, leveraging them to the needs and goals of process development teams within a structured, user-friendly environment.
As leaders in model-based bioprocess development and hybrid modeling, DataHow has analyzed hundreds of process data sets with many of the largest biopharmaceutical companies in the world. This expertise is made available within their turnkey solution, DataHowLab. With this single solution, process development teams can now truly understand their process data and have all the necessary tools to develop, optimize, and characterize their process across all phases of development faster and with less experimental effort.
About DataHow
DataHow is a forward-looking organization that develops unique bioprocess modeling solutions using Hybrid Modeling, combining mechanistic and machine learning models (AI). By incorporating process knowledge, hybrid models require less data, reducing experimentation and cost. This approach retains predictability from mechanistic models and flexibility from machine learning, adapting to various process configurations.
Custom Services
- Custom development projects
- Develop your digitalization strategy
- Proof of concept projects
- Digital readiness: preparing your data ecosystem
- Process data analytics and modeling support
Field of Expertise
- Mammalian Cell Culture
- Microbial Cell Culture
- Virus Production
- mRNA Processes
- Small Molecules Processes
Results
- Significant reduction in the number of experiments
- Acceleration of Process Development
- Adaptable and versatile models applicable to diverse scenarios
- Impressive cost reduction
- Optimal Process Design / Model-Based Process Control
Transfer Learning
DataHow empowers bioprocess development teams by providing them with the means to enhance their understanding and implement optimization models across a wide range of cell lines. DataHow offers a comprehensive suite of tools and mechanisms that leverage Transfer Learning, enabling the valuable knowledge and insights gained from one process to be effectively transferred and applied to another. This approach ultimately leads to improved efficiency and performance in bioprocessing operations.
Collaboration
DataHow’s cloud-based infrastructure and web-based software foster a collaborative learning culture, breaking down work silos within organizations. This approach enables colleagues to work jointly on projects, share insights and visualizations, and achieve collective success, driving continuous improvement.DataHow Lab Introduction
Working With DataHow Lab
Automated Sampling
Numera®
Advanced Bioprocess Sampling Solution
Numera® is a fully automated sampling system that enhances existing process analytical technologies, providing reliable real-time results 24/7. As part of a complete bioprocess automation strategy, Numera® combined with Lucullus® software is a seamless all-in-one sampling solution.
Numera Unique Features Include:
- Sampling from up to 16 different locations
- 2 to 3 ml sampling volume
- Sampling time ~8 minutes
- Sample storage and cooling
- Sample transfer and direct data integration to up to 4 analyzers
- Distinctive Filtration technology for cell removal
- Optional Dilution
Numera Modules
Control Module
- Touchscreen
- Configuration settings for system preparation, cleaning and settings
- Various communication ports
- Compressed air distribution
Multiplexer Module
- Multiplexing of up to 4 bioreactors per module
- Up to 4 modules per Numera® system
- Pinch valve sterility barrier with ethanol rinsing
- Sterile air blow back mechanism to prevent cross-contamination and preserve low volume sampling
Routing Module
- Individual sample distribution within one process
- Direct transfer to maximum 4 analyzers (biochemistry analyzers or cell counters)
Dilution Module
- Dilution from 1:2 to 1:20
- Up to 4 modules per Numera® system
- Precise and reproducible sample processing
Filtration Module
- Unique cross-flow filtration technology
- Low protein binding PES membrane
- Up to 700 filtrations per coil
- Membrane pore sizes: 0.22 μm, 0.45 μm, 0.65 μm and 1.2 μm
- Fresh membrane section for every filtration cycle avoiding cross-contamination and clogging
Axon HT
Advanced Auto Sampling for Ambr® 250 Multi-Parallel Bioreactors
This solution enables fully automated, high-throughput sampling from up to six Ambr® 250 systems — into multiple Analyzers, four times daily per bioreactor. As part of a scalable bioprocess automation platform, it is integrated with Siemens PLCs and Lucullus® SCADA to deliver around-the-clock data collection and advanced process control for optimized development workflows.
Features:
- Up to 6 Bioreactors from 6 AMBR® 250 systems can be sampled in parallel
- Each bioreactor can be sampled every 6 hours or 4 X per day (8 X per day is possible with additional analytical equipment*)
- Compatible with most analytical systems on the market (Cedex®, UPLC/LCMS, Nova FLEX, etc.)
True High-Throughput Bioprocessing
Integra1 64
Integra1 64 is a next-gen multi-parallel bioreactor platform that integrates automated upstream/downstream processing and PAT in one bioprocess automation–ready system.
Designed for micro to mid-scale process development, it accelerates ATMP timelines with a user-friendly, high-performance setup featuring eight independent reactor modules (total of 64 vessels) for unmatched throughput and control.
Each RAM Module Features
- 8 Bioreactors
- 5 Supply Vessels
- 180ml working volume per reactor (total volume 300ml)
- Liquid and gas control via transfer layer
- Sterile connections for all liquids and gases
- Sterile sampling port for each bioreactor
Each Integra1 64 Features
- 8 RAM Modules; 64 Bioreactors in total
- Full control of each bioreactor without compromise
- Fully integrated PAT and DSP workflows
Supported Processes
- Batch and Fedbatch
- Perfusion
- Cascaded Bioreaction
Main Application
- Clone Selection
- Early phase process parameter optimization
- Micro-production and DSP-development
Fully integrated workflows for both online PAT and DSP automation
Cost savings up to 2X within 10 years compared to other high-throughput systems
Feature and cost comparison of Integra1 64 to the leading MPB (multi-parallel bioreactor) system*
Modular, Customized Control Platforms
ProA PLC Upstream & Downstream Bioprocess Controller
Universal Multi-Sensor Transmitter Controller
ProA PLC is a highly flexible instrument capable of receiving a wide variety of digital or analog signals, displaying and re-transmitting the data over a single connection, and also providing standard bioprocess control functions for common Upstream and Downstream applications as part of broader bioprocess automation strategies.
This unit is supplied in either a benchtop, wall mount or skid mount IP66 enclosure and features a user-friendly multi-color touchscreen display providing On-Screen Process Information, Trending, Data Historian and Data Review Tools. Due to its open architecture, this platform is easily customizable to varying process conditions allowing integration of diverse sensors and establishing local control actions.
Base System Features
- Sensor Transmitter: 8 Analog/Digital sensor inputs including any combination of Flow, Pressure, pH, Conductivity, UV and Turbidity (expandable to higher number of inputs and different type of sensors – i.e. Process Scales, etc.)
- Modbus TCP, Modbus RTU, OPC and Analog Connectivity
- Standard PID Control for pump control based on Pressure/Flow thresholds
- Remote Browser or integral 7” or 10” HMI (IP66)
- Standard On-Screen Process Information, Trending, Historian and Data Review Tools
Wide Range of Applications for Data Transmission and Control
- Local Display of Process Conditions
Monitor processes in real-time where you need it - Multi-Sensor Transmitter
Convert eight or more different sensor types into a single OPC or Modbus connection - Mixing Applications
Buffer or media preparations - Perfusion Control
Control or monitor cell population by UV or OD, control feeding, bleeding and permeate - Continuous Centrifugation
Control or monitor cell concentration to stop overfilling / clogging of bowl
- Depth Filtration
Control peristaltic/diaphragm pumps - TFF/NFF Applications
Flat-sheet cassettes, hollow fibers or capsule filters - Integrity Testing
In-process testing for single-use assemblies or filters - Chromatography
pH, conductivity, back pressure and flow control - Buffer Exchange
Controlled by pH, conductivity, flow and pressure - Fill and Finish
Volumetric dosing based on total flow or pressure thresholds
Sensor Integration
The ProA PLC base system is designed to integrate eight standard sensor inputs. Number of sensor inputs can be expanded adding extra analog/digital input cards.
Most commonly connected sensors include:
| pH | Temperature |
| Conductivity | Turbidity/OD |
| UV/NIR | Cell Density |
| Pressure | Non-Invasive Flow |
| Load Cells | Precision Balances |
Pump Control for Accurate Fluid Transfer
The ProA PLC bioprocess controller provides accurate pump control for precise fluid transfer, process conditioning, fill and finish and other fluid transfer applications. Use your own pump or use a ProA Pump. ProA Pumps are supplied in all sizes, flow rates and configurations.