Category Archives: Reports

Perfusion Culture Optimization Through Accurate Metabolite Analysis Towards Integrating Continuous Perfusion Bioreactor with Continuous Countercurrent Tangential Chromatography (CCTC)

continuous countercurrent tangential chromatography cctc dvs inmotion

Soroosh Soltani1, Harleigh McNally1, Dmitriy Fedorenko1, Jasmine Tan1, Marcelo Luftman2, Justin Lussier2, Andrew Zydney3, Oleg Shinkazh1, * 1 Chromatan Corporation, 3 Spring House Innovation Park Suite 103, Lower Gwynedd, PA, 190022 PRO Analytics, LLC, Fairfield, NJ3 Department of Chemical Engineering, The Pennsylvania State University, University Park, PA 16802 * Communication concerning this manuscript should be […]

Dissolved CO2 Measurement In Bioprocess from R&D to Production

dissolved co2 measurement in bioprocess from R&D to production

Dissolved CO2 in Bioprocess CO2 has many important roles in growth and maintenance of cell and bacteria cultures. CO2 acts as an additive product which affects a wide range of metabolic and critical process parameters. It is important to track dCO2 in your cultures for: Intracellular/Extracellular pH changes Glycosylation and Molecule Stability Lactate production Monitor […]

Raman Spectroscopy in Bioprocessing: An Introduction to Spectroscopic Methods of Analysis & Applications in PAT

raman spectroscopy in bioprocessing

Introduction | What Is Spectroscopy? | Spectroscopic Techniques: Introduction to Spectroscopic Methods of Analysis in Bioprocessing: Luminescence | Absorption / NIR | Raman | Application of Raman Spectroscopy in Bioprocessing: PAT in Upstream | Raman in Upstream | PAT in Downstream | Raman in Downstream | Raman Analyzers Introduction The release of the FDA’s guidance […]

Achieving Superior Raman Measurements: Understanding and Avoiding Detector Saturation

One of the primary technological advantages of Tornado Raman analyzers over conventional Raman devices is the significantly higher optical efficiency delivered by our HTVS™ platform (described in this prior blog post). With 10x to 30x more photons per second, Tornado systems provide superior spectral data for better precision and sensitivity for PAT measurements, as we […]