Online Raman spectroscopy is a very well-established measurement technique for accurate measurements of glucose, lactate, viable cell density, and product concentration. Adaptive or closed-loop control strategies are now widely utilized to maintain glucose concentration at a fixed setpoint or to minimize lactate accumulation by adjusting the glucose feed rate. Additionally, this technology provides significant information about […]
Author Archives: Yigit Yoleri
Introduction The release of the FDA’s guidance on process analytical technology (PAT) for the biopharmaceutical industry has prompted the industry to embrace adaptive processes, employing advanced control strategies to ensure consistent product quality. Adoption of PAT has become very crucial as the bioprocess industry has grown rapidly over the past two decades. The development and […]
ProA Flow Sensors are ultrasonic clamp-on flow sensors that measure the flow rate to enable various applications. Integrating flow rate measurements into your existing process is key in automating these applications. For automation, ProA Flow Sensors use digital and analog communication protocols. Analog communication options: Digital communication options: Sensor Output and Cable Output Diagram ProA […]
Introduction | What Is Spectroscopy? | Spectroscopic Techniques: Introduction to Spectroscopic Methods of Analysis in Bioprocessing: Luminescence | Absorption / NIR | Raman | Application of Raman Spectroscopy in Bioprocessing: PAT in Upstream | Raman in Upstream | PAT in Downstream | Raman in Downstream | Raman Analyzers Introduction The release of the FDA’s guidance […]