Tornado Spectral Systems Raman Spectroscopy System Literature
White Papers and Application Note Summaries (complete form below to request full versions)
Residence time distribution (RTD) has become an essential parameter to characterize pharmaceutical manufacturing equipment in continuous manufacturing. This technology has been implemented in several production lines worldwide, as it allows characterization under potential process parameter perturbations to obtain a predictive control strategy. In this work, a Raman probe was integrated to detect low amounts of a tracer, changing many physical parameters such as the throughput, feed frame paddles speed, and the height of the powder bed in the chute connecting the blender with the tablet press. The goal of this work was to determine if a low level of the tracer material (1.5% w/w) is detectable under different manufacturing conditions. Utilizing Tornado Spectral System’s HyperFlux™ PRO Plus with their High Throughput Virtual Slit (HTVS™) technology yielded low signal-to-noise ratios and excellent performance predicting blend compositions as low as 1.5% w/w in the feed frame. These results indicate the robustness of the Tornado Raman system executing an extensive evaluation of a continuous manufacturing line sustaining the performance during ten days of data acquisition. The work shown in this note demonstrates the value added by the specificity of Raman technology. It also demonstrates, in particular, the sensitivity of the Tornado technology in validating the continuous blending and mixing processes for low dosage formulations.