Perfusion Cell Culture System

Introducing PerfuseCell’s CellMembra™ perfusion cell culture system, a world only family of single-use Pulsating-Tangential-Flow (PTF = next step after ATF). This system combines a mini Single-Use-Bioreactor (SUB), a Cross-Flow-Filter (CFF) and a Single-Use-Pump (SUP).

This size is designed for 100-400 ml Working Volume of mammalian cell cultivation operating at high cell density like +80 mio/cells/ml. Includes all the expected components, fully pre-assembled, fully single-use, ready to use right out of the box.

CellMembra comprises a configurable P-SUB optimized for use in single or in various parallel applications. From the SUB the integrated diaphragm SUP sucks and forces the broth along the CFF hollow fibers. The permeate passes through the CFF membrane and retentate, returning to the SUB. High quality single-use-sensor’s for DO, pH, Glycose and bio-mass measurements can be chosen. The that CellMembra fits any process control system.

CellMembra-500 Perfusion Cell Culture System Features:

  • No space consuming servo motor attached to the head plate – take advantage of Magnetic-Bottom-Drive (MBD)
  • Vessel cover, head plate designed with 4 single-use sensor ports and 6 ports for In&Out with small ID hoses
  • One-way circulated broth volume fully programmable and obtained velocity accurately measured and displayed – no guessing
  • HFF with 0,2 µm pore, 14 x 1,0 mm PES straw/lumen, 88 cm2 area, Luer-Lok side ports, (like D02-P20U-10-N) (or your preferred HFF)
  • The fully pre-assembled P-SUB unit is packed in dual film bags and precision irradiated – forget the autoclave
  • SUB dimension is OD 82 x 120 mm for Working Volume (WV) ranging from 100 ml up to 250 ml
  • Thermal control either electrical or with water – Heating-Support-Foot (HSF) available for 48 VDC, or for 110 VAC, or for 230 VAC, or for water

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