Reports

Preventing High-Density Cell Cultures from Fouling a Single-Use Continuous Centrifuge Using the ABER Optura SPY

Posted on by David Koechlein
Preventing High-Density Cell Cultures from Fouling SU Continuous Centrifuges Using the ABER OPTURA SPY
21
Oct

Authors: Holly Sullivan, David Koechlein, Justin Lussier Introduction The ability produce biological drugs at lower costs and higher yields has been a major focus for biomanufacturing. With the advent of Single-Use Bioreactors and improved molecular biology, cell cultures can be > 20 x 106 cells/mL (1). Clarification of these cultures typically involves a primary depth […]

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Reports

Online Raman Spectroscopy: Benefits of Metabolites Monitoring & Impact on Upstream Productivity

Posted on by Yigit Yoleri
online Raman spectroscopy: benefits of metabolites monitoring and impact on upstream productivity
30
Sep

Online Raman spectroscopy is a very well-established measurement technique for accurate measurements of glucose, lactate, viable cell density, and product concentration. Adaptive or closed-loop control strategies are now widely utilized to maintain glucose concentration at a fixed setpoint or to minimize lactate accumulation by adjusting the glucose feed rate. Additionally, this technology provides significant information about […]

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Reports

Pharmaceutical Dosing Technology: Enhancing Precision with Peristaltic Pumps, Flow Sensors, and Real-Time Control

Posted on by Dan Matlock
pharmaceutical dosing technology: Enhancing Precision with Peristaltic Pumps, Flow Sensors & Real-Time Control
20
Sep

Introduction Dosing Systems and Dosing Technology for Pharma Applications Accurate dosing is a critical task in the pharmaceutical industry, particularly in areas such as cell and gene therapy, stem cell research, and small-scale pharmaceutical production. The integration of high-precision peristaltic pumps, ultrasonic flow sensors, and a real-time measurement and control system significantly enhances dosing accuracy […]

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Reports

How Do Peristaltic Pumps Work?

Posted on by David Koechlein
how do peristaltic pumps work
25
Jul

What Are Peristaltic Pumps? Peristaltic pumps — also called tubing pumps, roller pumps, or hose pumps — are important tools for medical, laboratory, and bioprocess/biopharma processes. They are a laboratory staple commonly used for processes such as fluid transfers, filtration/chromatography applications, volume dosing/metering, and volume control of all types of vessels. Peristaltic pumps are positive […]

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Reports

Optimizing Lab Analyzer Communications: Analog Protocols Preserve Critical Quality Attributes to Data Loggers and Bioreactors

Posted on by Justin Lussier
analog protocols preserve critical quality attributes to data loggers
10
Nov

Introduction In the bioprocessing industry, bioreactor controllers are often used to tightly control many parameters within a bioreactor process run. The measurements that are controlled are called Critical Quality Attributes (CQAs) and include real-time pH, dissolved oxygen (DO), CO2, temperature, biomass and metabolites. Digital vs Analog Communication Protocols in Biotech Analyzers often have many different […]

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