GMP Bioreactor

Constructed in solid AISI 316L SS frames, ePROD systems are designed for efficient culture growth in microbial and cell culture applications. Standard PLC control platforms with eSCADA ADVANCED software provide high flexibility of programing and configurations.

Multi-use GMP bioreactor systems are supplied with 316L vessels from 100 to 4000 Liters. ePROD single-use GMP systems include a dual purpose control platform which can be used on either microbial or cell culture applications with SUV in the 100 to 1000L range.

Precise analytical measurements of pH, DO, temperature and antifoam level are standard. Optional dCO2, biomass and off gas measurements. Fully configurable for mammalian or microbial cultures. A 400W Servomotor drive provides precise speed control allowing efficient mixing for optimal performance.

• Standard Sizes: 100, 200, 400, 1000, 2000 and 4000 liter working volume
• 1:2 standard diameter-to-height ratio on cell culture vessels
• 1:3 standard diameter-to-height ratio on microbial vessels
• Microbial Configuration includes 3×6 blade Rushton impeller
• Cell Culture Configuration includes 2x pitch blade impellers with addition of Mass Flow Controllers for precise air, O2, N2, and CO2 addition
• Multiple options including Micro spargers, external feeding pumps, additional sensors integration, etc.
• Agitation control using high precision Servomotor

• Wide selection of standard sizes including 30L, 50L, 100L, 300L and 1000L. Other sizes on request.
• Advanced eBAG 3D STR manufactured at TECNIC ISO7 Clean Room for highest sterility including full certification
• Mammalian configuration with pitch blade single-use impellers
• Microbial configuration with single-use Rushton impellers
• Standard ports for exhaust connection, overlay gas entrance, pH/pO2/Temperature sensors and liquid transfer or sampling
• Flexible bag design allows customization to fit specific process requirements

Five Layer Film structure serves a specific function to optimize product integrity, durability, longevity and sterility:

•  Layer 1: (50 um) Low-Density Polyethylene (LDPE) provides mechanical strength and resistance to external factors
•  Layer 2: (10 um) Thermoplastic Interlayer Elastomer (TIE) bonding layer for structural integrity preventing delamination
•  Layer 3: (20 um) Ethylene Vinyl Alcohol (EOH) gas barrier
•  Layer 4: (10 um) Second Thermoplastic Interlayer Elastomer (TIE) as bonding layer
•  Layer 5: (230 um) Ultralow-Density Polyethylene (ULPDE) in direct contact with process liquids. Provides a Toxic-Free biocompatible environment.

TECNIC is a global manufacturer of high-quality, scalable bioprocess equipment for laboratory, pilot plant and GMP operations.

Their products/systems portfolio includes a comprehensive line of Bioreactors, TFF Systems, Mixing & Storage Equipment, and Buffer & Media Preparation skids in a wide range of sizes. This company focuses on innovation, providing standard state-of-the-art proven systems or customized solutions tailored to end users’ specific requirements. All products are available in reusable or single-use format. TECNIC’s supplies includes a large variety of single-use accessories designed for all their equipment including 2D and 3D bags, single-use bioreactor vessels and custom fluid path tubing/manifolds/filter kits. They also provide an extensive range of rigid plastic, borosilicate glass (jacketed and non-jacketed) and SS vessels and components.