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Large Surface Area

Single use large surface micro carrier adherent cells bioreactor

Compatibility

Compatible with most serum-free media

Robust Technology

Combination technology: Single-use or multiple-use​ vessels

Cell Lines

Established for most cell lines

Whole Cell Sampling

You can remove a piece of the macrocarrier with cells adhered to it

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Scale Up

Linear scale-up with harvesting capabilities. Read whitepaper.

Additional Features

  • TIDE Motion / Alternate Aeration & Nutrition Phase: Nutrition cycles maximize O2 transfer and reduced shear stress. Ideal to convert from roller bottle to single-use closed system. 1 CelCradle® bottle = 20 roller bottles (850cm2)
  • Single-use closed system for autologous and allogeneic cell therapies
  • Celfeeder for automatic perfusion culture control
  • Accurate pH and DO control for inoculation
cell line applications

Established On Most Cell Line Applications:

  • Mammalian and insect cell culture
  • Fermentation
  • Monoclonal antibody production
  • Gene and cell therapy (autologous & allogeneic)
  • Viral vector production
  • Pharmacokinetics study
  • Vaccine production
  • Drug discovery
  • Protein production
  • Proteome research
  • Exosomes
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TIDE MOTION IN CelCradle®

The principle of ‘Tide Motion’ in CelCradle® contains the packed bed (BioNOC™ II) and the media reservoir in the same bottle. As the bellows are pushed up, the cells attached to the carriers will be submerged to the culture media, whereas cells are taking in nutrition. As the bellows are release, the cells are exposed to air in the environment taking in aeration.

nutrition aeration illustration
celcradle whitepaper

Linear Scalability of CAR Lentivirus Production in Single-Use TideMotion Bioreactors, from Lab to Industrial Scale

In this whitepaper, we focus on the linear scalability of CelCradle® to TideCell® on transfection efficiency of HEK-293T using 4-plasmid lentiviral system to support large-scale LVV production.

Download Whitepaper
esco celcradle models

A Cradle for your Adherent Cells

Want to learn more about this bench-scale bioreactor system that can support high adherent cell density cultures? Contact us today for details.